Özet:
Bisphenol A (BPA), an endocrine-disrupting chemical (EDC), has strong potential for daily exposure to humans and animals due to its persistence and widespread in the environment, so its effects directly concern public health. Although invertebrates represent important components of aquatic ecosystems and are at significant risk of exposure, there is little information about the biological effects of EDCs in these organisms. Astacus leptodactylus used in this study is one of the most consumed and exported freshwater species in Europe. In this study, the 96-h effect of BPA on A. leptodactylus was examined using various biomarkers. The LC50 value of BPA was determined as 96.45 mg L-1. After 96 h of exposure to BPA, there were increases in superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione S-transferase (GST), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) activities and levels of malondialdehyde (MDA), and total oxidant status context (TOSC), and there were decreases in the activity of glutathione reductase (GR), carboxylesterase (CaE), acetylcholinesterase (AChE), Na+/K+ ATPase, Mg2+ ATPase, Ca2+ ATPase, and total ATPase and the total antioxidant context (TAC). From the results of this study, it can be concluded that BPA has significant toxic effects on A. leptodactylus based on the selected biochemical parameters of antioxidant, cholinergic, detoxification, and metabolic systems in crayfish even at low doses. Thus, it can be said that BPA can seriously threaten the aquatic ecosystem and public health.
