Adıyaman Üniversitesi Kurumsal Arşivi

Biochemical constituent, enzyme inhibitory activity, and molecular docking analysis of an endemic plant species,Thymus migricus

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dc.contributor.author Aras, Abdulmelik
dc.contributor.author Türkan, Fikret
dc.contributor.author Yildiko, Ümit
dc.contributor.author ve öte.
dc.date.accessioned 2025-09-29T10:56:13Z
dc.date.available 2025-09-29T10:56:13Z
dc.date.issued 2020
dc.identifier.issn 0366-6352
dc.identifier.uri http://dspace.adiyaman.edu.tr:8080/xmlui/handle/20.500.12414/6744
dc.description.abstract Medicinal plants have been used traditionally since ancient times as alternative medications to treat various human diseases.In this work, we examined the chemical constituent, antioxidant activity, and enzyme inhibition of an endemic plantThymus migricus. The plant extracts showed remarkable inhibition effects against the acetylcholinesterase (AChE), butyrylcholinesterase (BChE), glutathione S-transferase (GST), and alpha-glycosidase (alpha-Gly) enzymes that are linked with some metabolic disorders. IC(50)values (concentration of a sample to inhibit 50% of enzyme activity) for AChE, BChE, GST, and alpha-Gly were found as 18.23 mg/mL, 17.77 mg/mL, 31.5 mg/ml, and 16.5 mg/mL, respectively. Antioxidant activities of water extract ofT. migricus(WET) and methanol extract ofT. migricus(MET) were determined using four in vitro techniques. The extracts showed considerable antioxidant actions on all four techniques. In addition, quinic acid (18.30 mg/g), chlorogenic acid (0.94 mg/g), cynaroside (0.49 mg/g), luteolin (0.21 mg/g), andp-coumaric acid (0.19 mg/g) were characterized as major phenolic compounds using advanced LC-MS/MS technique. The interactions of some phenolic compounds with the enzymes have been investigated using molecular docking studies. The docking analysis results revealed that the interactions of the major compounds of the plant with AChE, BChE, GST, and alpha-Gly enzymes are responsible for the inhibitory activity. tr
dc.language.iso en tr
dc.publisher SPRINGER INT PUBL AG tr
dc.subject Antioxidant tr
dc.subject Enzyme inhibition tr
dc.subject Phenolic compounds tr
dc.subject Thymus migricus tr
dc.subject Docking tr
dc.title Biochemical constituent, enzyme inhibitory activity, and molecular docking analysis of an endemic plant species,Thymus migricus tr
dc.type Article tr
dc.contributor.department Igdir Univ, Fac Sci & Arts, Dept Biochem tr
dc.contributor.department Igdir Univ, Hlth Serv Vocat Sch tr
dc.contributor.department Kafkas Univ, Architecture & Engn Fac, Dept Bioengn tr
dc.identifier.endpage 1146 tr
dc.identifier.issue 3 tr
dc.identifier.startpage 1133 tr
dc.identifier.volume 75 tr
dc.source.title CHEMICAL PAPERS tr


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