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Can renalase be a novel candidate biomarker for distinguishing renal tumors?

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dc.contributor.author Akkoç, Ramazan Fazıl
dc.contributor.author Aydın, Süleyman
dc.contributor.author Göksu, Mustafa
dc.contributor.author ve öte.
dc.date.accessioned 2025-09-29T10:56:04Z
dc.date.available 2025-09-29T10:56:04Z
dc.date.issued 2020
dc.identifier.issn 1052-0295
dc.identifier.uri http://dspace.adiyaman.edu.tr:8080/xmlui/handle/20.500.12414/6740
dc.description.abstract Renalase (RNLS) is synthesized mainly in renal tissues. The function of RNLS in cancerous renal tissues has not been investigated. We investigated the synthesis of RNLS in chromophobe renal cell carcinoma, papillary renal cell carcinoma and clear cell renal cell carcinoma with Fuhrman grades (FG): FG1, nucleoli are absent or inconspicuous and basophilic; FG2, nucleoli are conspicuous and eosinophilic and visible but not prominent; FG3, nucleoli are conspicuous and eosinophilic; FG4, extreme nuclear pleomorphism, multinucleate giant cells, and/or rhabdoid and/or sarcomatoid differentiation. We used 90 tissue samples including 15 healthy controls, 15 chromophobe renal cell carcinoma tissues and 10 papillary renal cell carcinoma renal tissues: 12 FG1, 14 FG 2, 14 FG 3 and 10 FG4. RNLS in the tissue samples was measured using enzyme linked immunosorbent assay and immunostaining of RNLS in these tissues. RNLS was significantly greater in the chromophobe renal cell carcinoma and papillary renal cell carcinoma tissues than the control. The least amount of RNLS was found in the renal tissues of clear cell renal cell carcinoma FG1; the amount of RNLS increased as the FG grades increased. Because RNLS increased significantly in renal tissues due to cancer, except for clear cell renal cell carcinoma FG1, RNLS may be useful biomarker for distinguishing grades of renal cancer. Because RNLS increases cell survival, anti-RNLS preparations may be useful for treating cancer in the future. tr
dc.language.iso en tr
dc.publisher TAYLOR & FRANCIS LTD tr
dc.subject Biomarker tr
dc.subject carcinoma tr
dc.subject ELISA tr
dc.subject fuhrman nuclear grade tr
dc.subject human tr
dc.subject renal tumors tr
dc.subject renalase tr
dc.title Can renalase be a novel candidate biomarker for distinguishing renal tumors? tr
dc.type Article tr
dc.contributor.authorID 0000-0002-0559-8932 tr
dc.contributor.department Firat Univ, Sch Med, Dept Anat tr
dc.contributor.department Elazig Fethi Sekin City Hosp, Dept Cardiovasc Surg, tr
dc.contributor.department Adiyaman Univ, Sch Med, Dept Pediat Surg tr
dc.identifier.endpage 525 tr
dc.identifier.issue 7 tr
dc.identifier.startpage 520 tr
dc.identifier.volume 96 tr
dc.source.title BIOTECHNIC & HISTOCHEMISTRY tr


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