Adiyaman University Repository

Glabridin attenuates airway inflammation and hyperresponsiveness in a mice model of ovalbumin-induced asthma

Show simple item record

dc.contributor.author Doğan, Muhammed Fatih
dc.contributor.author Parlar, Ali
dc.contributor.author Cam, Saliha Aysenur
dc.contributor.author Tosun, Elif Merve
dc.contributor.author Uysal, Fatma
dc.contributor.author Arslan, Seyfullah Oktay
dc.date.accessioned 2025-09-29T10:55:55Z
dc.date.available 2025-09-29T10:55:55Z
dc.date.issued 2020
dc.identifier.issn 1094-5539
dc.identifier.uri http://dspace.adiyaman.edu.tr:8080/xmlui/handle/20.500.12414/6736
dc.description.abstract Asthma is an inflammatory disease of the airways of the lungs, which is characterized by airflow obstruction and bronchospasms. Glabridin is a major flavonoid, especially found in root of Glycyrrhiza glabra, and has several pharmacological activities, including antioxidant and anti-inflammatory effects. The anti-asthmatic effect and possible mechanism of glabridin, however, have not been revealed so far. The aim of this study is to investigate the effects and possible mechanisms of glabridin against ovalbumin (OVA)-induced airway hyperresponsiveness (AHR) and inflammation in mice. In male BALB/c mice, asthma was induced by intraperitoneal (i.p) injection of OVA mixed with 2 mg aluminium hydroxide on days 0, 14 and boosted with OVA aerosol challenge on days 21, 22, and 23. Mice were either treated with dexamethasone (i.p, 1 mg/kg) or glabridin (10, 20, and 30 mg/kg) from days 18-23. Pulmonary function parameters such as peak inspiratory flow, peak expiratory flow, tidal volume, expiratory volume, the frequency of breathing, enhanced pause values were evaluated by using whole-body plethysmography. Measurements were performed at baseline and following methacholine (50 mg/mL) challenges. In addition, white blood cells (WBC) count, total protein, and IgE levels were measured in bronchial alveolar lavage fluid (BALF), lung, and serum, respectively. Glabridin (20 or 30 mg/kg) significantly attenuated (p < 0.05) OVA-induced alteration in respiratory parameters. Elevated counts of total WBC, differential WBC (neutrophils, lymphocytes, monocytes, and eosinophils) in BALF and the total protein in lungs and BALF were significantly decreased (p < 0.05) by glabridin (20 or 30 mg/kg). It also significantly attenuated the increased serum IgE levels (p < 0.05). As glabridin reduces the level of serum IgE, the total protein and the count of WBC and improves respiratory function, it may be a novel therapeutic agent in asthma. tr
dc.language.iso en tr
dc.publisher ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD tr
dc.subject Glabridin tr
dc.subject Asthma tr
dc.subject Plethysmography tr
dc.subject Ovalbumin tr
dc.title Glabridin attenuates airway inflammation and hyperresponsiveness in a mice model of ovalbumin-induced asthma tr
dc.type Article tr
dc.contributor.authorID 0000-0002-4656-3402 tr
dc.contributor.authorID 0000-0003-3326-8487 tr
dc.contributor.authorID 0000-0002-3975-928X tr
dc.contributor.authorID 0000-0001-9328-9373 tr
dc.contributor.department Pamukkale Univ, Fac Med, Dept Pharmacol tr
dc.contributor.department Adiyaman Univ, Fac Med, Dept Pharmacol tr
dc.contributor.department Ankara Yildirim Beyazit Univ, Fac Med, Dept Pharmacol tr
dc.contributor.department Adiyaman Univ, Expt Anim Prod Applicat & Res Ctr tr
dc.identifier.volume 63 tr
dc.source.title PULMONARY PHARMACOLOGY & THERAPEUTICS tr


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account