Morphological and antibacterial effects of silver, magnesium, silicon and strontium modified calcium phosphate bone cements prepared by the sol-gel method

Abstract

In this study, the sol-gel method was used to add MgO and SrBr2 to biografts containing Ca(NO3)(2)center dot 4H(2)O, SiO2, P2O5, H3BO3 and AgNO3. In addition, urea (15-35% by weight) was added to these biografts in different ratios. FTIR, XRD and SEM-EDX analyses were performed in order to observe the morphological effects. Antibacterial tests were carried out using S.aureus and E.coli bacteria. As a result of FTIR analysis, it was observed that H-OH, CO,3- CO33-, PO43-, Si-O and Si-O-Si compound structures were formed in the biografts. XRD analysis was found that HA (Hydroxyapatite), beta-TCP, CaSiO3, CaMgSi2O6, Ca3MgSi2O8, CaMgSi2O6 and Mg17Sr2 compound structures were formed. Antibacterial analysis with E. coli showed that all biografts except the one that contained the highest amount of urea (35% by weight) yielded colony counting values close to the negative control. For S. aureus, the opposite result was observed.