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The protective effect of resveratrol against risperidone-induced liver damage through an action on FAS gene expression

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dc.contributor.author Azirak, Sebile
dc.contributor.author Bilgiç, Sedat
dc.contributor.author Tastemir Korkmaz, Deniz
dc.contributor.author ve öte.
dc.date.accessioned 2025-02-17T10:40:57Z
dc.date.available 2025-02-17T10:40:57Z
dc.date.issued 2019
dc.identifier.issn 0231-5882
dc.identifier.uri http://dspace.adiyaman.edu.tr:8080/xmlui/handle/20.500.12414/5812
dc.description.abstract The purpose of the study is to examine the protective effect of resveratrol on the fatty acid synthase gene expression against the side-effects of risperidone in an experimental model in rat liver. In this study, thirty-five female Spraque-Dawley rats were divided into five groups (n = 7): Control, RIS (2 mg/kg risperidone daily), RSV1 (2 mg/kg risperidone + 20 mg/kg resveratrol), RSV2 (2 mg/kg risperidone + 40 mg/kg resveratrol), and RSV3 group (2 mg/kg risperidone + 80 mg/kg resveratrol). On treatment day 15, liver tissue was taken for analysis. The resveratrol treatment significantly reduced weight gain as opposed to the risperidone administration. Moreover, the fatty acid synthase gene expression level increased significantly in RSV1 group (p = 0.011). In addition, resveratrol enhanced the total antioxidant status, high-density lipoprotein cholesterol levels and decreased alanine aminotransferase, aspartate aminotransferase, total cholesterol, gamma glutamyl transpeptidase, low density lipoprotein cholesterol, oxidative stress index, triglycerides, and total oxidant status levels significantly (p < 0.05). In conclusion, this study revealed that treatment with resveratrol might protect liver tissue against the side-effects of risperidone over fatty acid synthase gene expression. Resveratrol could be an effective course of therapy for enhancing therapeutic efficacy. tr
dc.language.iso en tr
dc.publisher AEPRESS SRO tr
dc.subject Risperidone tr
dc.subject Resveratrol tr
dc.subject Fatty acid synthase tr
dc.subject Liver tr
dc.subject Apoptosis tr
dc.title The protective effect of resveratrol against risperidone-induced liver damage through an action on FAS gene expression tr
dc.type Article tr
dc.contributor.authorID 0000-0001-8410-2685 tr
dc.contributor.department Adiyaman Univ, Vocat Sch Hlth Serv, tr
dc.identifier.endpage 225 tr
dc.identifier.issue 3 tr
dc.identifier.startpage 215 tr
dc.identifier.volume 38 tr
dc.source.title GENERAL PHYSIOLOGY AND BIOPHYSICS tr


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