Adıyaman Üniversitesi Kurumsal Arşivi

New bioactive silver(I) complexes: Synthesis, characterization, anticancer, antibacterial and anticarbonic anhydrase II activities

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dc.contributor.author Özdemir, Ümmuhan O.
dc.contributor.author ve diğerleri...
dc.date.accessioned 2024-11-29T08:44:50Z
dc.date.available 2024-11-29T08:44:50Z
dc.date.issued 2017
dc.identifier.issn 0022-2860
dc.identifier.uri http://dspace.adiyaman.edu.tr:8080/xmlui/handle/20.500.12414/5545
dc.description.abstract Silver(I) complexes of alkyl sulfonic acide hydrazides were newly synthesized as homologous series. Methanesulfonic acide hydrazide (L1), ethanesulfonic acide hydrazide (L2), propanesulfonic acide hydrazide (L3) and butanesulfonic acide hydrazide (L4) were used for complexation with Ag(I) ions. The silver complexes obtained in the mol ratio of 1:2 have the structural formula as Ag(L1)(2)NO3 (I), Ag(L2)(2)NO3 (II). Ag(L3)(2)NO3 (III), (Ag(L4)(2)NO3 (IV). The Ag(I) complexes exhibit distorted linear two -fold coordination in [AgL2](+) cations with uncoordinated nitrates. Ligands are chelated with silver(I) ions through unsubstituted primary nitrogen in hydrazide group. Ag(I) complexes were characterized by using elemental analysis, spectroscopic methods (FT-IR, LC-MS), magnetic susceptibility and conductivity measurements. Silver(1) complexes were optimized using PBEPBE/LanL2DZ/DEF2SV basic set performed by DFT method with the Gaussian 09 program package. The geometrical parameters, frontier molecular orbitals (HOMOs and LUMOs) and molecular electrostatic potential (MEP) mapped surfaces of the optimized geometries were also determined by this quantum set. The anticancer activities of silver(I) complexes on MCF-7 human breast cancer cell line were investigated by comparing IC50 values. The antibacterial activities of complexes were studied against Gram positive bacteria: S. aureus ATCC 6538, B. subtilis ATCC 6633, B. cereus NRRL-B-3711, E. faecalis ATCC 29212 and Gram negative bacteria: E. coli ATCC 11230, P. aeruginosa ATCC 15442, K. pneumonia ATCC 70063 by using disc diffusion method. The inhibition activities of Ag(I) complexes on carbonic anhydrase II enzyme (hCA II) were also investigated by comparing IC50 and Ki values. The biological activity screening shows that Ag(I) complex of butanesulfonicacidehydrazide (IV) has the highest activity against tested breast cancer cell lines MCF-7, Gram positive/Gram negative bacteria and carbonic anhydrase II (hCA II) isoenzyme. tr
dc.language.iso en tr
dc.publisher Elsevier tr
dc.subject Silver(I) complexes tr
dc.subject Alkyl sulfonic acide hydrazide tr
dc.subject Anticancer tr
dc.subject Antibacterial tr
dc.subject Anti carbonic anhydrase II tr
dc.title New bioactive silver(I) complexes: Synthesis, characterization, anticancer, antibacterial and anticarbonic anhydrase II activities tr
dc.type Article tr
dc.contributor.authorID 0000-0001-9161-9367 tr
dc.contributor.department Gazi Univ, Fac Sci, Dept Chem, Ankara, Turkey tr
dc.identifier.endpage 63 tr
dc.identifier.startpage 55 tr
dc.identifier.volume 1138 tr
dc.source.title Journal Of Molecular Structure tr


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