Adıyaman Üniversitesi Kurumsal Arşivi

Biochemical investigation of the toxic effects of acrylamide administration during pregnancy on the liver of mother and fetus and the protective role of vitamin E

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dc.contributor.author Erdemli, Mehmet
dc.contributor.author ve diğerleri...
dc.date.accessioned 2024-10-28T06:56:39Z
dc.date.available 2024-10-28T06:56:39Z
dc.date.issued 2017
dc.identifier.issn 1476-7058
dc.identifier.uri http://dspace.adiyaman.edu.tr:8080/xmlui/handle/20.500.12414/5341
dc.description.abstract Objectives: To investigate the toxic effects occurring in the liver tissues of the pregnant rats and the fetuses, which are administered acrylamide and vitamin E as a protector during pregnancy. Materials and methods: This research was conducted with the permission of Laboratory Animals Ethical Board of Inonu University Faculty of Medicine. Forty rats, of which their pregnancy is validated via vaginal smear, were distributed into five different groups. On the 20th day of pregnancy, pregnant rats and fetuses are decapitated. Malondialdehyde (MDA), reduced glutathione (GSH), total antioxidant status (TAS), total oxidant status (TOS) and xanthine oxidase (XO) levels were measured in the liver samples taken from mother and fetuses. Results: It was detected that acrylamide administered during pregnancy increased MDA, TOS, XO levels statistically significantly and decreased the GSH level (p <= 0.05) in the pregnant rat liver tissue when compared to all other groups. In the vitamin E administered group; GSH, TAS levels significantly increased statistically and TOS and XO levels dropped to levels of the control group (p <= 0.05), in comparison to all other groups. Among all groups, no biochemical changes were observed in the fetus liver tissue (p > 0.05). Conclusion: The liver of pregnant rats functions as a protective pre-filter by detoxifying acrylamide effectively and the acrylamide that reaches fetus liver is detoxified by the cytochrome P-450 system of the fetus liver. To be able to figure out the biochemical mechanism, more advanced studies are needed. tr
dc.language.iso en tr
dc.publisher Taylor & Francis tr
dc.subject Acrylamide tr
dc.subject Liver tr
dc.subject Oxidative stress tr
dc.subject Pregnant rat tr
dc.subject vitamin E tr
dc.title Biochemical investigation of the toxic effects of acrylamide administration during pregnancy on the liver of mother and fetus and the protective role of vitamin E tr
dc.type Article tr
dc.contributor.department Inonu Univ, Med Fac, Dept Med Biochem, TR-44280 Malatya, Turkey tr
dc.identifier.endpage 848 tr
dc.identifier.issue 7 tr
dc.identifier.startpage 844 tr
dc.identifier.volume 30 tr
dc.source.title Journal of Maternal-Fetal & Neonatal Medicine tr


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