Adıyaman Üniversitesi Kurumsal Arşivi

Prediction of new potential associations between LncRNAs and environmental factors based on KATZ measure

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dc.contributor.author Vural, Huseyin
dc.contributor.author Kaya, Mehmet
dc.date.accessioned 2024-03-13T05:39:14Z
dc.date.available 2024-03-13T05:39:14Z
dc.date.issued 2018
dc.identifier.issn 0010-4825
dc.identifier.uri http://dspace.adiyaman.edu.tr:8080/xmlui/handle/20.500.12414/4951
dc.description.abstract The associations between genetic and environmental factors (EFs) are significant to understand the development and progression of many complex human diseases. There have been many research studies concerning genetic factors (protein-coding genes, microRNAs) and EFs but limited research addressing the associations between long noncoding RNAs (lncRNAs) and EFs. LncRNAs of more than 200 nucleotides are an important class of non coding transcripts and are effective in the organization of gene expressions and, therefore, on the formation of diseases. Environmental factors can alter the expression patterns of some lncRNAs, so a thorough understanding of the associations between lncRNAs and environmental factors will contribute to the understanding of the mechanisms of many complex diseases at the molecular level. In this study, we have developed a model based on the KATZ measure to find potential new associations between lncRNAs and EFs by using the DLREFD database, which contains proven associations between lncRNAs and EFs. The KATZ measure and Gaussian interaction profile kernel similarity were used to predict new potential associations between lncRNAs and EFs. The AUC results obtained by global leave-one-out cross-validation and 2-fold and 5-fold cross-validations were 0.855, 0.827, 0.838, respectively. These results show that our model can predict new potential associations between lncRNAs and EFs with high reliability. Also, the results obtained in case studies demonstrate the effectiveness of our model. tr
dc.language.iso en tr
dc.publisher PERGAMON-ELSEVIER SCIENCE LTD tr
dc.subject Long non-coding RNA tr
dc.subject Environmental factors tr
dc.subject Link prediction tr
dc.subject KATZ measure tr
dc.title Prediction of new potential associations between LncRNAs and environmental factors based on KATZ measure tr
dc.type Article tr
dc.contributor.authorID 0000-0001-9290-6317 tr
dc.contributor.authorID 0000-0003-2995-8282 tr
dc.contributor.department Adiyaman Univ, Dept Comp Technol, tr
dc.contributor.department Firat Univ, Dept Comp Engn tr
dc.identifier.endpage 125 tr
dc.identifier.startpage 120 tr
dc.identifier.volume 102 tr
dc.source.title COMPUTERS IN BIOLOGY AND MEDICINE tr


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