Adıyaman Üniversitesi Kurumsal Arşivi

Alkyl sulfonic acide hydrazides: Synthesis, characterization, computational studies and anticancer, antibacterial, anticarbonic anhydrase II (hCA II) activities

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dc.contributor.author Özdemir, Ümmühan Ö.
dc.contributor.author İlbiz, Firdevs
dc.contributor.author Gündüzalp, Ayla Balaban
dc.contributor.author ve diğerleri...
dc.date.accessioned 2023-01-20T10:57:26Z
dc.date.available 2023-01-20T10:57:26Z
dc.date.issued 2015
dc.identifier.issn 0022-2860
dc.identifier.uri http://dspace.adiyaman.edu.tr:8080/xmlui/handle/20.500.12414/4361
dc.description.abstract Methane sulfonic acide hydrazide, CH3SO2NHNH2 (1), ethane sulfonic acide hydrazide, CH3CH2SO2NHNH2 (2), propane sulfonic acide hydrazide, CH3CH2CH2SO2NHNH2 (3) and butane sulfonic acide hydrazide, CH3CH2CH2CH2SO2NHNH2 (4) have been synthesized as homologous series and characterized by using elemental analysis, spectrophotometric methods (H-1-C-13 NMR, FT-IR, LC-MS). In order to gain insight into the structure of the compounds, we have performed computational studies by using 6 311G(d, p) functional in which B3LYP functional were implemented. The geometry of the sulfonic acide hydrazides were optimized at the DFT method with Gaussian 09 program package. A conformational analysis of compounds were performed by using NMR theoretical calculations with DFT/B3LYP/6 311++G(2d, 2p) level of theory by applying the (GIAO) approach. The anticancer activities of these compounds on MCF-7 human breast cancer cell line investigated by comparing IC50 values. The antibacterial activities of synthesized compounds were studied against Gram positive bacteria; Staphylococcus aureus ATCC 6538, Bacillus subtilis ATCC 6633, Bacillus cereus NRRL-B-3711, Enterococcus faecalis ATCC 29212 and Gram negative bacteria; Estherichia coli ATCC 11230, Pseudomonas aeruginosa ATCC 15442, Klebsiella pneumonia ATCC 70063 by using the disc diffusion method. The inhibition activities of these compounds on carbonic anhydrase II enzyme (hCA II) have been investigated by comparing IC50 and Ki values. The biological activity screening shows that butane sulfonic acide hydrazide (4) has more activity than the others against tested breast cancer cell lines MCF-7, Gram negative/Gram positive bacteria and carbonic anhydrase II (hCA II) isoenzyme. tr
dc.language.iso en tr
dc.publisher Elsevier tr
dc.subject Alkyl sulfonic acide hydrazide tr
dc.subject Sulfonamide tr
dc.subject Anticancer tr
dc.subject Antibacterial tr
dc.subject Anti carbonic anhydrase II isoenzyme tr
dc.subject Computational studies tr
dc.title Alkyl sulfonic acide hydrazides: Synthesis, characterization, computational studies and anticancer, antibacterial, anticarbonic anhydrase II (hCA II) activities tr
dc.type Article tr
dc.contributor.authorID 0000-0001-9161-9367 tr
dc.contributor.department Gazi Univ, Fac Sci, Dept Chem, Ankara, Turkey tr
dc.identifier.endpage 474 tr
dc.identifier.startpage 464 tr
dc.identifier.volume 1100 tr
dc.source.title Journal Of Molecular Structure tr


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