Adıyaman Üniversitesi Kurumsal Arşivi

A functional HOTAIR rs920778 polymorphism does not contributes to gastric cancer in a Turkish population: a case-control study

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dc.contributor.author Bayram, Süleyman
dc.contributor.author Ülger, Yakup
dc.contributor.author Sümbül, Ahmet Taner
dc.contributor.author ve diğerleri...
dc.date.accessioned 2023-01-20T10:56:40Z
dc.date.available 2023-01-20T10:56:40Z
dc.date.issued 2015
dc.identifier.issn 1389-9600
dc.identifier.uri http://dspace.adiyaman.edu.tr:8080/xmlui/handle/20.500.12414/4354
dc.description.abstract An aberrant up-regulation of HOX transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA (lncRNA), is associated with human cancers including gastric cancer (GC) and worse clinicopathological features. A naturally occurring functional single nucleotide polymorphism (SNP) rs920,778 (C -> T) in the intronic enhancer of HOTAIR gene has been demonstrated to affect HOTAIR expression and cancer susceptibility. To investigate the association of the HOTAIR rs920778 polymorphism on the risk of GC susceptibility in Turkish population, a hospital-based case-control study was carried out consisting of 104 GC and 209 healthy control subjects matched on age and gender. The genotype frequency of HOTAIR rs920778 polymorphism was determined by using TaqMan Real-Time Polymerase Chain Reaction. No statistically significant differences were found in the allele or genotype distributions of the HOTAIR rs920778 polymorphism among GC and healthy control subjects (P > 0.05). Our results demonstrate that the HOTAIR rs920778 polymorphism has not been in any major role in genetic susceptibility to gastric carcinogenesis, at least in the population studied here. Independent studies are needed to validate our findings in a larger series, as well as in patients of different ethnic origins. tr
dc.language.iso en tr
dc.publisher Springer tr
dc.subject Gastric cancer tr
dc.subject HOTAIR tr
dc.subject lncRNA tr
dc.subject HOTAIR rs920778 polymorphism tr
dc.subject Genetic susceptibility tr
dc.title A functional HOTAIR rs920778 polymorphism does not contributes to gastric cancer in a Turkish population: a case-control study tr
dc.type Article tr
dc.contributor.authorID 0000-0002-5573-906X tr
dc.contributor.department Adiyaman Univ, Adiyaman Sch Hlth, Dept Nursing, TR-02040 Adiyaman, Turkey tr
dc.contributor.department Adiyaman Univ, Educ & Res Hosp, Dept Gastroenterol, TR-02040 Adiyaman, Turkey tr
dc.contributor.department Mustafa Kemal Univ, Fac Med, Dept Med Oncol, TR-31000 Antakya, Turkey tr
dc.identifier.endpage 567 tr
dc.identifier.issue 4 tr
dc.identifier.startpage 561 tr
dc.identifier.volume 14 tr
dc.source.title Familial Cancer tr


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