dc.contributor.author |
Bayram, Süleyman |
|
dc.contributor.author |
Ülger, Yakup |
|
dc.contributor.author |
Sümbül, Ahmet Taner |
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dc.contributor.author |
ve diğerleri... |
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dc.date.accessioned |
2023-01-20T10:56:40Z |
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dc.date.available |
2023-01-20T10:56:40Z |
|
dc.date.issued |
2015 |
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dc.identifier.issn |
1389-9600 |
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dc.identifier.uri |
http://dspace.adiyaman.edu.tr:8080/xmlui/handle/20.500.12414/4354 |
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dc.description.abstract |
An aberrant up-regulation of HOX transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA (lncRNA), is associated with human cancers including gastric cancer (GC) and worse clinicopathological features. A naturally occurring functional single nucleotide polymorphism (SNP) rs920,778 (C -> T) in the intronic enhancer of HOTAIR gene has been demonstrated to affect HOTAIR expression and cancer susceptibility. To investigate the association of the HOTAIR rs920778 polymorphism on the risk of GC susceptibility in Turkish population, a hospital-based case-control study was carried out consisting of 104 GC and 209 healthy control subjects matched on age and gender. The genotype frequency of HOTAIR rs920778 polymorphism was determined by using TaqMan Real-Time Polymerase Chain Reaction. No statistically significant differences were found in the allele or genotype distributions of the HOTAIR rs920778 polymorphism among GC and healthy control subjects (P > 0.05). Our results demonstrate that the HOTAIR rs920778 polymorphism has not been in any major role in genetic susceptibility to gastric carcinogenesis, at least in the population studied here. Independent studies are needed to validate our findings in a larger series, as well as in patients of different ethnic origins. |
tr |
dc.language.iso |
en |
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dc.publisher |
Springer |
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dc.subject |
Gastric cancer |
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dc.subject |
HOTAIR |
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dc.subject |
lncRNA |
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dc.subject |
HOTAIR rs920778 polymorphism |
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dc.subject |
Genetic susceptibility |
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dc.title |
A functional HOTAIR rs920778 polymorphism does not contributes to gastric cancer in a Turkish population: a case-control study |
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dc.type |
Article |
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dc.contributor.authorID |
0000-0002-5573-906X |
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dc.contributor.department |
Adiyaman Univ, Adiyaman Sch Hlth, Dept Nursing, TR-02040 Adiyaman, Turkey |
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dc.contributor.department |
Adiyaman Univ, Educ & Res Hosp, Dept Gastroenterol, TR-02040 Adiyaman, Turkey |
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dc.contributor.department |
Mustafa Kemal Univ, Fac Med, Dept Med Oncol, TR-31000 Antakya, Turkey |
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dc.identifier.endpage |
567 |
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dc.identifier.issue |
4 |
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dc.identifier.startpage |
561 |
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dc.identifier.volume |
14 |
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dc.source.title |
Familial Cancer |
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