Adıyaman Üniversitesi Kurumsal Arşivi

Effect of sugammadex on rocuronium induced changes in pancreatic mast cells

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dc.contributor.author Kalkan, Yıldıray
dc.contributor.author Tümkaya, Levent
dc.contributor.author Bostan, Habib
dc.contributor.author ve diğerleri...
dc.date.accessioned 2023-01-20T10:56:34Z
dc.date.available 2023-01-20T10:56:34Z
dc.date.issued 2015
dc.identifier.issn 0748-2337
dc.identifier.uri http://dspace.adiyaman.edu.tr:8080/xmlui/handle/20.500.12414/4351
dc.description.abstract Mast cells play a vital role in hypersensitivity reactions. Rocuronium is known to cause mast cell mobilization, hypersensitivity, and pancreatitis. The aim of this study was to investigate the effects of sugammadex on pancreatic changes due to rocuronium. A total of 42 Sprague-Dawley male rats were divided into six equal groups to receive either rocuronium 1mg/kg intravenously (i.v., R group), rocuronium 1mg/kg+sugammadex 16mg/kg i.v. (RS16 group), rocuronium 1mg/kg+sugammadex 96mg/kg i.v. (RS96 group), sugammadex 16mg/kg (S16), sugammadex 96mg/kg i.v. (S96 group), or 0.9% sodium chloride (control group). Sugammadex was administered 5s later following rocuronium. In R group, mast count was higher, and the distribution rate of granules and nuclear changes were different compared with other groups. Distribution rate of granules in groups S16 and S96 were similar to the control group and lower compared with other groups. The amount of mast cells and granule density in groups RS16 and RS96 was lower compared with R group. The amount of mast cells in groups RS16 and RS96 was significantly lower compared with other treatment groups. These results suggest that sugammadex may have an inhibitory effect on mobilization and morphological changes in pancreatic mast cells induced by administration of rocuronium and sugammadex in rats. tr
dc.language.iso en tr
dc.publisher Sage Publications tr
dc.subject Sugammadex tr
dc.subject Rocuronium tr
dc.subject Pancreatic mast cells tr
dc.subject Rat tr
dc.title Effect of sugammadex on rocuronium induced changes in pancreatic mast cells tr
dc.type Article tr
dc.contributor.authorID 0000-0001-6098-5962 tr
dc.contributor.authorID 0000-0001-7391-2180 tr
dc.contributor.department Recep Tayyip Erdogan Univ, Fac Med, Dept Histol & Embryol, TR-52324 Rize, Turkey tr
dc.contributor.department Inst Forens Med, Minist Justice, Istanbul, Turkey tr
dc.identifier.endpage 746 tr
dc.identifier.issue 8 tr
dc.identifier.startpage 738 tr
dc.identifier.volume 31 tr
dc.source.title Toxicology and Industrial Health tr


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