Efficiency of Intravitreal Ranibizumab Injection in Wet Age-Related Macular Degeneration

Abstract

Purpose: To evaluate the efficiency of the treatment of intravitreal ranibizumabin on the functions of lesion size and visual outcome in neovascular age-related macular degeneration cases.

Material and Methods: Age-related macular degeneration diagnosis of 71eyes of 59 patients were analyzed retrospectively. Best-corrected visual acuity (BCVA), biomicroscopic examination, intra ocularpressure and fundus examinations were noted about the cases. In order to evaluate the effiency of IVR treatment, widest lesion diameter (WLD) of choroidal neovascularization (CNV) and BCVA were compared statistically, before and after treatment according to fundus fluorescein angiography (FFA).

Results: The mean follow-upperiod was 14 +/- 5 months. Snellen BCVA was found 0.13 +/- 0.09 before treatment and was found 0.22 +/- 0.16 after treatment according to Snellen. A statistically significant increase was detected in BCVA after IVR teatment. WLD was calculated 4040 +/- 117 mu m before treatment and 3620 +/- 128 mu m after treatment. After IVR treatment a statistically significant decrease was founded in WLD.

Conclusion: In our study, an increase in BCVA and a decrease in WLD were observed with the treatment of IVR in wet AMD cases. IVR was made out to be an effective and safe treatment. It can be thought that an obvious improvement was achieved acording to anatomic and visual acuity.