Adıyaman Üniversitesi Kurumsal Arşivi

Amelioration of subchronic acrylamide toxicity in large intestine of rats by organic dried apricot intake

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dc.contributor.author Erdemli, Mehmet Erman
dc.contributor.author Doğan, Zümrüt
dc.contributor.author Çiğremiş, Yılmaz
dc.date.accessioned 2023-01-06T05:36:51Z
dc.date.available 2023-01-06T05:36:51Z
dc.date.issued 2015
dc.identifier.issn 1300-0152
dc.identifier.uri http://dspace.adiyaman.edu.tr:8080/xmlui/handle/20.500.12414/4203
dc.description.abstract Acrylamide (AA) has neurotoxic, mutagenic, and genotoxic effects in humans and experimental animals. Fruit consumption is important for human health, because fruits are the source of many nutrients such as vitamins, minerals, carotenoids, dietary fiber, and phytonutrients. Many agricultural products provide natural melatonin in the diet. At the onset of the study, rats were weighted and randomly divided into four groups each containing 10 rats as follows: group 1: control (fed with normal diet and normal drinking water); group 2: apricot (fed with a daily diet with 5% apricot and normal drinking water); group 3: AA (administered daily acrylamide at 500 mu g/kg b.w. via drinking water and fed a normal diet); group 4: apricot-AA (administered daily acrylamide at 500 mu g/kg b.w. via drinking water and fed with a diet with 5% apricot). The diet schedule was continued for 12 weeks. At the end of the study, samples of large intestine were collected for biochemical analyses. The highest lipid peroxidation (as malondialdehyde, MDA) levels were observed in the AA groups, but MDA levels decreased significantly (P < 0.05) with apricot intake. Glutathione peroxidase activity in the apricot-AA group was higher than in the other three groups (P < 0.05). Glutathione S-transferase (GST) enzyme activity increased significantly in the AA group as compared with the other groups (P < 0.05). However, GST activity was significantly (P < 0.05) decreased by the apricot-supplemented diet. GST-Pi mRNA levels in the AA group increased significantly (P < 0.05) as compared with the other groups. In conclusion, the results of the current study demonstrated that AA caused large intestine damage and showed the efficiency of apricot in preventing this damage by inhibiting lipid peroxidation and improving antioxidant enzyme activities. tr
dc.language.iso en tr
dc.publisher TÜBİTAK tr
dc.subject Apricot tr
dc.subject Acrylamide tr
dc.subject Rat tr
dc.subject Large intestine tr
dc.subject GST-Pi tr
dc.subject Antioxidant enzymes tr
dc.title Amelioration of subchronic acrylamide toxicity in large intestine of rats by organic dried apricot intake tr
dc.type Article tr
dc.contributor.authorID 0000-0003-4596-7525 tr
dc.contributor.authorID 0000-0002-8600-0946 tr
dc.contributor.authorID 0000-0001-7131-2317 tr
dc.contributor.department Inonu Univ, Fac Med, Dept Med Biochem, Malatya, Turkey tr
dc.contributor.department Adiyaman Univ, Fac Med, Dept Anat, Adiyaman, Turkey tr
dc.contributor.department Inonu Univ, Fac Med, Dept Med Biol & Genet, Malatya, Turkey tr
dc.identifier.endpage 878 tr
dc.identifier.issue 6 tr
dc.identifier.startpage 872 tr
dc.identifier.volume 39 tr
dc.source.title Turkish Journal Of Biology tr


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