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Evaluation of early subclinical cardiotoxicity of chemotherapy in breast cancer

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dc.contributor.author Alıcı, Hayri
dc.contributor.author Balakan, Ozan
dc.contributor.author Süleyman, Ercan
dc.contributor.author ve diğerleri...
dc.date.accessioned 2022-12-30T08:28:59Z
dc.date.available 2022-12-30T08:28:59Z
dc.date.issued 2015
dc.identifier.issn 2149-2263
dc.identifier.uri http://dspace.adiyaman.edu.tr:8080/xmlui/handle/20.500.12414/4151
dc.description.abstract Objective: Cardiac effects of chemotherapy are usually recognized after clinical symptom or sign occurrence in patients with breast cancer. In this study, we aimed to determine the potential subclinical cardiotoxic effects of chemotherapy that were given lower dosage than well known cardiac safety dosage limits in patients with breast cancer during early period. Methods: Fifty-one patients consecutively enrolled to this prospective cohort study. All patients were diagnosed as breast cancer at oncology hospital in University of Gaziantep. Before chemotherapy, all of the patients underwent to detailed ECG and echocardiography (ECHO) examinations. After 6 months, detailed ECG and ECHO examinations were repeated and compared with baseline values. Statistical analysis was performed using Shapiro-Wilk tests, Student t-test and Spearman correlation test. Results: The average age of patients was 51 and one was male. Statistically significant decrease in ejection fraction was found after treatment (62.3%+/- 3.3 and 59.9%+/- 5.9, p=0.002). Evaluation of diastolic parameters; significant increase in the transmitral A flow velocity and significant decrease of E/A ratio were observed on Doppler ECHO analysis (77.4 +/- 19.1 cm/sec versus 86 +/- 18 cm/sec, p<0.001; 1.01 +/- 0.3 versus 0.9 +/- 0.2, p=0.03, respectively). On tissue Doppler analysis we observed that significant reduction in the value of E' and significantly increase E/E' ratio were present (12.5 +/- 3.6 cm/sec versus 10.7 +/- 2.9 cm/sec, p=0.001; 6.6 +/- 2.9 versus 7.7 +/- 3.3, p=0.04, respectively). Conclusion: Chemotherapy has detrimental subclinical effect on both of systolic and diastolic function in early six months period despite the prescription of lower dosage of chemotherapy than well-known cardiac safety dosage limits. Tissue Doppler imaging may be more sensitive than ECG, conventional ECHO and Doppler for determining the subclinical cardiac damage. tr
dc.language.iso en tr
dc.publisher Aves tr
dc.subject Breast cancer tr
dc.subject Chemotherapy tr
dc.subject Echocardiography tr
dc.subject Tissue Doppler imaging tr
dc.subject Cardiotoxicity tr
dc.title Evaluation of early subclinical cardiotoxicity of chemotherapy in breast cancer tr
dc.type Article tr
dc.contributor.authorID 0000-0002-4926-5785 tr
dc.contributor.authorID 0000-0003-0942-0848 tr
dc.contributor.department 25 Aralik State Hosp, Clin Cardiol, Gaziantep, Turkey tr
dc.contributor.department Sutcu Imam Univ, Fac Med, Dept Oncol, Kahramanmaras, Turkey tr
dc.contributor.department Gaziantep Univ, Fac Med, Dept Cardiol, Gaziantep, Turkey tr
dc.identifier.endpage 60 tr
dc.identifier.issue 1 tr
dc.identifier.startpage 56 tr
dc.identifier.volume 15 tr
dc.source.title Anatolian Journal Of Cardiology tr


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