Effects of the Coronary Collateral Circulation on the Tp-e Interval and Tp-e/QT Ratio in Patients with Stable Coronary Artery Disease

Abstract

BackgroundThe clinical utility of the Tp-e interval and Tp-e/QT ratio in the risk stratification of ventricular arrhythmic events is controversial. Therefore, we investigated the impact of CCC on these electrocardiographic indexes in the course of stable CAD.

MethodsTwo hundred three consecutive patients with stable CAD who underwent coronary angiography and had documented total occlusion of one of the major coronary arteries were enrolled in this prospective cross-sectional study. The Tp-e interval and Tp-e/QT ratio were measured by 12-lead electrocardiogram.

ResultsThe Tp-e interval, cTp-e interval, Tp-e/QT ratio, and cTp-e/QT ratio were lower in the grade 3 CCC group compared with the others in all leads. Multivariate linear regression analyses was performed to identify the clinical factors affecting the cTp-e interval and was indicated that age ( = 0.261, P < 0.001), male sex ( = 0.334, P < 0.001), poor Rentrop grade ( = -0.228, P < 0.001), and NLR ( = 0.137, P = 0.027) were independent predictors of a prolonged cTp-e interval.

ConclusionIt could be concluded that the decreased dispersion of ventricular repolarization might contribute to the lower incidence of ventricular arrhythmias and SCD in CAD patients with a good CCC.