Adıyaman Üniversitesi Kurumsal Arşivi

Endothelial nitric oxide synthase levels and their response to exercise in patients with slow coronary flow

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dc.contributor.author Taşolar, Hakan
dc.contributor.author Eyyüpkoca, Ferhat
dc.contributor.author Aktürk, Erdal
dc.contributor.author Karakuş, Yasin
dc.contributor.author Cansel, Mehmet
dc.contributor.author Yağmur, Jülide
dc.contributor.author Özyalın, Fatma
dc.contributor.author Altun, Burak
dc.contributor.author Pekdemir, Hasan
dc.date.accessioned 2022-10-14T05:57:47Z
dc.date.available 2022-10-14T05:57:47Z
dc.date.issued 2013
dc.identifier.issn 1995-1892
dc.identifier.uri http://dspace.adiyaman.edu.tr:8080/xmlui/handle/20.500.12414/3692
dc.description.abstract Background: Endothelial dysfunction plays a key role in the aetiopathogenesis of slow coronary flow (SCF) even if there is no obstructive epicardial lesion. Reduced plasma levels of endothelial nitric oxide synthase (eNOS) are an important indicator of endothelial dysfunction. We aimed to determine plasma levels of eNOS and their relationship with exercise in patients with SCF. Methods: Twenty-two patients with SCF in at least one coronary artery and 17 healthy individuals were included in this study. The TIMI frame count method was used to determine SCF. Plasma levels of eNOS before and after effort were determined in the patient and control groups. Results: Basal eNOS levels in the patient group were lower than in the control group (p = 0.040), and plasma eNOS levels after exercise decreased more significantly in the patient group compared to the control group (p = 0.002). Median decreases of eNOS in response to exercise were higher in the SCF group than in the control group (p < 0.001), and the decrease observed in the control group was not statistically significant (p = 0.35). There were significantly negative correlations between TIMI frame count and plasma levels of eNOS at baseline and after exercise (r = -0.51, p = 0.015, r = -0.58, p = 0.005, respectively). Moreover, there was also a positive correlation between the rate-pressure product and plasma levels of eNOS after exercise in patients with SCF (r = 0.494, p = 0.019). Conclusion: Our findings indicate an important pathophysiological relationship between the severity of SCF in which endothelial dysfunction plays a role in its pathogenesis and the level of circulating plasma levels of eNOS. tr
dc.language.iso en tr
dc.publisher Clınıcs Cardıve Publ Pty Ltd tr
dc.subject Endothelial nitric oxide synthase tr
dc.subject Slow coronary flow tr
dc.subject Endothelial dysfunction tr
dc.subject Eercise tr
dc.subject Rate-pressure product tr
dc.title Endothelial nitric oxide synthase levels and their response to exercise in patients with slow coronary flow tr
dc.type Article tr
dc.contributor.authorID 0000-0002-1249-7240 tr
dc.contributor.authorID 0000-0003-2630-3619 tr
dc.contributor.authorID 0000-0003-4740-4371 tr
dc.contributor.authorID 0000-0001-6486-6389 tr
dc.contributor.authorID 0000-0002-4913-5120 tr
dc.contributor.department Adiyaman Univ, Training & Res Hosp, Dept Cardiol, tr
dc.contributor.department Inonu Univ, Dept Cardiol, Fac Med, tr
dc.contributor.department Malatya State Hosp, tr
dc.contributor.department Inonu Univ, Dept Med Biochem, Fac Med, tr
dc.contributor.department Mart Univ, Dept Cardiol, Fac Med, tr
dc.identifier.endpage 359 tr
dc.identifier.issue 9-10 tr
dc.identifier.startpage 355 tr
dc.identifier.volume 24 tr
dc.source.title Cardıovascular Journal Of Afrıca tr


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