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Association of the Nramp1 gene polymorphisms and clinical forms in patients with tuberculosis

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dc.contributor.author Hanta, İsmail
dc.contributor.author Taştemir Korkmaz, Deniz
dc.contributor.author Demirhan, Osman
dc.contributor.author Hanta, Deniz
dc.contributor.author Kuleci, Sedat
dc.contributor.author Seydaoğlu, Gülşah
dc.date.accessioned 2022-05-31T08:21:57Z
dc.date.available 2022-05-31T08:21:57Z
dc.date.issued 2012
dc.identifier.issn 0006-9248
dc.identifier.uri http://dspace.adiyaman.edu.tr:8080/xmlui/handle/20.500.12414/3055
dc.description.abstract Background: Recent studies have reported that Nramp1 polymorphisms might have an important role in the development of tuberculosis in various populations. In this study, we aimed to determine Nramp1 polymorphisms in our patients with tuberculosis population. Methods: We enrolled 127 patients with active tuberculosis and 116 healthy adults with similar age and gender. Peripheral blood samples were taken for determining the Nramp1 polymorphisms. By using Polymerase Chain Reaction (PCR) - Restriction Fragment Length Polymorphisms (RFLP) technique, we evaluated the polymorphisms of Nramp1 at the regions of D543N and INT4. Results: We found that the Nramp1 polymorphisms at the region of D543N (OR: 0.44, 95%CI: 0.09-2.06 for GA allele) were not a risk factor for tuberculosis. Furthermore, we could not able to detect Nramp1 polymorphism at the regions of INT4 (OR: 0.97, 95%CI: 0.55-1.72 for GC allele and OR: 0.90, 95%CI: 0.21-3.77 for CC allele). Conclusion: The findings of the present study do not support the hypothesis that Nramp1 at the regions of D543 and INT4 might play a role in influencing the growth of bacilli and progression of cavitary tuberculosis rather than susceptibility to M. tuberculosis infection. Future studies are needed to elucidate the role of Nramp1 variants in the pathogenesis of tuberculosis (Tab. 3, Ref. 29). Full Text in PDF www.elis.sk. tr
dc.language.iso en tr
dc.publisher Comenıus unıvsch medıcıne tr
dc.subject Tuberculosis tr
dc.subject Pathogenesis tr
dc.subject Nramp1 gene polymorphisms tr
dc.title Association of the Nramp1 gene polymorphisms and clinical forms in patients with tuberculosis tr
dc.type Article tr
dc.contributor.authorID 0000-0001-5844-8914 tr
dc.contributor.authorID 0000-0002-0876-406X tr
dc.contributor.authorID 0000-0002-6464-3270 tr
dc.contributor.department Cukurova Univ, Fac Med, Dept Chest Dis, tr
dc.contributor.department Adiyaman Univ, Vocat Sch Hlth Serv, tr
dc.contributor.department Cukurova Univ, Fac Med, Dept Med Biol & Genet, tr
dc.contributor.department Numune Educ & Res Hosp, Dept Pediat, tr
dc.contributor.department Cukurova Univ, Fac Med, Dept Biostat tr
dc.identifier.endpage 660 tr
dc.identifier.issue 11 tr
dc.identifier.startpage 657 tr
dc.identifier.volume 113 tr
dc.source.title Bratislava Medical Journal-Bratislavske Lekarske Listy tr


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